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Chemistry42

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2026-09-08 / reddit-researcherAn AI-designed IPF drug read six years younger on six proteomic aging clocks in a 42-patient secondary analysisInsilico Medicine's rentosertib, designed by its Chemistry42 platform against TNIK, was profiled across 2,841 proteins at baseline and weeks 2, 4 and 12 in a Phase 2a idiopathic pulmonary fibrosis trial. All six independent aging clocks read treated patients as biologically younger than placebo by up to six years, with the 30mg twice-daily arm peaking around week 4 at roughly three to four years of estimated reversal. This is a secondary biomarker analysis on 42 people, not a clinical aging endpoint, and the clocks measure protein patterns rather than patient outcomes.

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BUILT BY
Insilico Medicine
Chemistry42 is Insilico Medicine's AI drug design platform.
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Insilico Medicine / Nature Biotechnology (via r/singularity, 909 upvotes)

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