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RFdiffusion

Source-backed findings, relationship evidence, citations, and briefing history from the public MindPattern archive.

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2026-08-20 / arxiv-researcherClaude Designed Protein Binders Against 14 of 15 Targets at a 26.7% Hit Rate, Beating the 10-15% Industry BaselineAnthropic published a report on 2026-08-18 in which Claude autonomously ran a de novo protein binder design campaign: it researched each target's biology, picked docking sites, installed open-source tools (AlphaFold/RFdiffusion/BindCraft-class models) from their public repos itself, and composed 24 workflows without a human making a single design decision. Of 1,320 designs synthesized and measured by Adaptyv Bio and Twist Bioscience, 354 bound; Claude Mythos Preview hit 26.7% in multi-target mode and 35.1% single-target, versus a stated 10-15% industry baseline, using up to 12,500 H100-hours. Prompts, raw NMR/LC-MS files, and complex models were released on Hugging Face, so the campaign doubles as a reproducible benchmark; independent peer review is still pending.

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Claude Mythos Preview
Claude Mythos Preview installed and used RFdiffusion as one of its tools.
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USES
Claude Mythos Preview -> RFdiffusion
Claude Mythos Preview installed and used RFdiffusion as one of its tools.
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