OpenAI Case Study: GPT-5 Pro Cracks Immunologist Derya Unutmaz's 3-Year-Old T-Cell Mystery

OpenAI·medium signal

OpenAI published a case study on June 23 detailing how immunologist Derya Unutmaz used GPT-5 Pro to crack a puzzle his lab had wrestled with since 2022, feeding the model unpublished flow-cytometry data on CD4+ T cells under glucose/2-DG conditions. GPT-5 proposed that disrupted N-linked glycosylation during priming — driven by memory rather than naïve T cells — explained the anomaly, a hypothesis that then had to survive bench validation. For builders, it's a concrete, expert-validated example of LLMs compressing hypothesis-generation timelines in real research, while still operating inside a frame built by human scientists.