TrialCalibre: Fully Automated Causal Engine for Clinical Trial Benchmarking and Observational Study Calibration

arXiv·low signal

Habibdoust and Song (arXiv 2604.25832) present TrialCalibre, an AI system that automates the full pipeline from RCT identification to observational trial calibration with deterministic guardrails for regulated clinical decisions. While healthcare-specific, the architecture — an autonomous agent pipeline with hard guardrails, audit trails, and regulatory compliance in a high-stakes domain — mirrors the emerging pattern of agent systems in regulated industries seen in Corti and Mizuho's Agent Factory.