Cloudflare Python Workers went GA after two years, with FastAPI, Django and asyncpg working natively.

The September 21 release runs WSGI/ASGI connectors on a Pyodide runtime following the PEP 783 / PyEmscripten packaging standard. Socket support through the Workers connect API means aiomysql and asyncpg reach Postgres and MySQL via Hyperdrive, and the JS interop boilerplate is gone, so no more to_js(..., dict_converter=js.Object.fromEntries) to touch a binding. The limit that stays: any package with native C/C++/Rust extensions still needs cross-compilation to WebAssembly. (Cloudflare)